Serum selenium in head and neck cancer patients--a new marker of tumor activity?
نویسندگان
چکیده
OBJECTIVE The purpose of this work was to investigate the relationship between the tumor volume and the endogenous selenium levels in untreated head and neck cancer patients. MATERIALS AND METHODS One hundred consecutive patients were included in this study. We measured the endogenous levels of selenium in the serum and the whole blood of all patients by atomic absorption spectrometry. Additionally, the activity of glutathione peroxidase and the concentration of malonedialdehyde were observed. The resectability of the tumor was used as an independent marker of the tumor volume. RESULTS Thirty-one out of 100 patients had resectable tumors, while 69 patients were characterized as unresectable. The following median results were obtained (resectable versus unresectable): Serum Se 0.90 micromol/l versus 0.78 micromol/l (p=0.024); whole blood Se 1.00 micromol/l versus 0.93 micromol/l (p=0.139); glutathione peroxidase 145 U/l versus 148 U/l (p=0.93); and malonedialdehyde 2.21 mmol/l versus 2.6 mmol/l (p=0.84). CONCLUSION The concentration of serum selenium shows a significant relationship with tumor resectability in patients with advanced head and neck cancer.
منابع مشابه
Soluble HER-2 in Patients with Head and Neck Squamous Cell Carcinoma
Introduction: The presence of HER-2 has been shown to be a prognostic factor in many kinds of cancers, but its role in head and neck squamous cell carcinoma (HNSCC) is not still defined. The purpose of the current study is to investigate the role of HER-2 in HNSCC and its correlation with various clinicopathologic parameters. Materials and Methods: Peripheral blood samples were obtained ...
متن کاملغلظت خونی نشان تومورهای در گردش کارسینوم سلول فلسی در بیماران مبتلا به تومورهای سرو گردن
For determining the sensitMty and specificity of serum level of circulating sec tumor marker, for diagnosis of head and neck primary tumors and metastatic types of see and non-See tumors, the present study was conducted. 89 patients with head and neck tumors (thyroid tumors were excluded) were studied during a one year period. When the questionnaires were completed and radiologic measures and c...
متن کاملOCT-4 Is a Good Predictive Biomarker for Local Recurrence in Head and Neck Basal Cell Carcinoma
Background and Aim: Basal cell carcinoma (BCC) is considered to be the most common malignancy in humans and occurs primarily in the skin especially in the head and neck region. Considering the high recurrence rate of the tumor, finding a marker for prediction of recurrence is very important. Cancer stem cells are a small subpopulation in the tumors that are related to tumorigenesis and recurren...
متن کاملThe Effect of Oral Selenium on Radiotherapy Induced Mucositis in Patients with Head and Neck Cancer: a Pilot double-blind study
Background & Aims: The purpose of this study was to evaluate the efficacy of oral selenium in alleviation of oral mucositis induced by radiotherapy in head and neck cancer patients. Methods: In a randomized double blind pilot study, 35 patients under radiotherapy, due to primary tumors localized in the head or neck, who had at least two oral sites were st...
متن کاملThe Effect of Oral Selenium on Radiotherapy Induced Mucositis in Patients with Head and Neck Cancer:a Pilot double-blind study
Background & Aims: The purpose of this study was to evaluate the efficacy of oral selenium in alleviation of oral mucositis induced by radiotherapy in head and neck cancer patients. Methods: In a randomized double blind pilot study, 35 patients under radiotherapy, due to primary tumors localized in the head or neck, who had at least two oral sites were studied. They were randomly divided into t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Anticancer research
دوره 25 3A شماره
صفحات -
تاریخ انتشار 2005